Carbohydrates

Carbohydrates play a vital role in therapeutic drug development, but their structural complexity presents significant synthetic challenges. At CRAMSN Research Park, we specialize in the synthesis of a wide range of carbohydrates, including monosaccharides, polysaccharides, iminosugars, carbocyclic sugars, nucleosides, locked nucleic acids (LNA), glycopeptides, and thioglycosides.

Our expertise spans complex multi-step carbohydrate synthesis, employing both linear and convergent synthetic approaches. We focus on selective protection and deprotection strategies, ensuring precise functional group control throughout the synthesis. Additionally, we have extensive experience in managing moisture-sensitive glycosylation reactions, enabling high selectivity and efficiency.

We are proficient in handling triflates, azide transfer reactions, and oxidative transformations, which are essential for modifying carbohydrate structures for therapeutic applications. Our capabilities include the use of glycosyl donors such as S-Methyl and S-Tolyl, allowing for efficient glycosylation and structural diversification.

Purification and isolation of carbohydrates, particularly water-soluble intermediates, require specialized techniques. We employ advanced purification strategies to ensure high product purity and yield. Through our expertise in carbohydrate chemistry, CRAMSN Research Park supports the development of innovative solutions for pharmaceutical and biotechnological applications.