Specialized Chemistry+
CRAMSN Research Park is a reliable partner for development, clinical, and commercial manufacturing across a diverse portfolio of chemistry and technology platforms. With over two decades of experience, we specialize in handling complex chemistries and advanced technologies, ensuring seamless scalability, regulatory compliance, and commercialization.
Our state-of-the-art infrastructure supports a wide range of chemistry technologies and specialized platforms, including peptides, steroids, hormones, oligonucleotides, carbohydrates, and High Potent APIs (HPAPIs). By combining expertise in process development, analytical sciences, and cGMP manufacturing, we offer tailored solutions to meet the evolving needs of our global clients.
With a commitment to quality, innovation, and operational excellence, CRAMSN Research Park ensures efficient, cost-effective, and phase-appropriate development from early discovery to large-scale commercial production.
Peptides
Peptide Development Expertise: Extensive experience in developing various peptide classes, including linear and branched peptides (up to 40 AA), depsipeptides, stapled peptides, and peptide derivatives (steroids, lipids, carbohydrates, PEG). Access to unnatural amino acids via asymmetric hydrogenation.
State-of-the-Art Manufacturing: Capable of producing 1-2 kg per batch using solid, solution, and hybrid phase techniques. Manufacturing site inspected by US FDA, MHRA, PMDA, and other regulatory bodies.
Advanced Purification & Analysis: Equipped with RPHPLCs with PAT tools, fully automated ion chromatography, and Hastelloy ANFDs for closed-loop filtration. Strong analytical support for impurity profiling and characterization.
Carbohydrates
Expertise in All Classes of Carbohydrates:
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Monosaccharides
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Polysaccharides
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Iminosugars
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Carbocyclic sugars
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Nucleosides
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Locked Nucleic Acids (LNA)
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Glycopeptides
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Thioglycosides
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Carbohydrate polymers
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Iron carbohydrate complexes
Capabilities in Complex Multi-Step Carbohydrate Synthesis:
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Linear & convergent synthesis
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Selective protection and deprotection strategies
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Controlled selectivity in moisture-sensitive glycosylation
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Handling of reactive intermediates like triflates, azide transfer, and oxidations
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Experience with glycosyl donors such as S-Methyl and S-Tolyl
Large-Scale Manufacturing & Purification :
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Expertise in commercial-scale telescoping for carbohydrate production
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Various purification techniques :
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C-18 Purification (up to 2 kg of crude compounds)
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Gel Permeation Chromatography (GPC) purification
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Strong Anion Exchange (SAX) purification
Operational Efficiency & Impurity Control :
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Focused on reducing chromatographic separations
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Utilizing solubility-based and solvent extraction techniques for impurity removal
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Streamlined processes for improved scalability and efficiency
Steroids
Extensive Experience in Steroid APIs :
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Over two decades of collective expertise in developing and manufacturing steroid APIs.
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Proven track record in delivering legacy steroid assets for customers.
Expertise Across Various Steroid Classes :
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Human and veterinary steroids.
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Glucocorticoids, hormonal steroids, and fluorinated steroids.
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Steroid derivatives, including peptides, small molecules, lipids, carbohydrates, and PEGs.
Dedicated Steroid Manufacturing Facility :
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Specialized modules equipped with SS, GL, and Hastelloy reactors.
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Capability to handle batch sizes up to 300 kg.
Operational Efficiency & Impurity Control :
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Focused on reducing chromatographic separations
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Utilizing solubility-based and solvent extraction techniques for impurity removal
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Streamlined processes for improved scalability and efficiency
High Potent Small Molecule Development and Manufacturing Services
Expertise in Highly Potent Small Molecule Development & Manufacturing :
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Specialized in API and intermediate development for oncology and other high-potency drugs.
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Development lab in Hyderabad capable of handling molecules with OEL as low as 0.1 µg/m³.
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Batch output ranging from 25 to 50 grams.
World-Class Manufacturing Capabilities :
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One of the largest global capacities for highly potent compounds (OEL 0.1–1 µg/m³, OEB 5).
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Facilities audited by US FDA and other leading regulatory agencies.
Advanced Processing & Scalability :
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Expertise in specialized unit operations like micronization and spray drying.
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Flexible production capacity ranging from 500 grams to multi-ton scale.
