Biocatalysis:

Application of enzyme-catalyzed transformations to achieve high chemo-, regio-, and stereoselectivity under mild conditions, supporting sustainable and cost-effective process development.

Resolution Techniques

Expertise in classical and modern resolution methods, including diastereomeric salt formation, enzymatic resolution, and preparative chiral chromatography to deliver high enantiopurity for regulatory-grade intermediates and APIs.

Purification & Separation Techniques

Comprehensive capabilities in purification and separation, encompassing crystallization, distillation, preparative HPLC, simulated moving bed chromatography, and membrane-based techniques—ensuring consistent product quality and regulatory compliance.

High Potent APIs

At CRAMSN Research Park, we are committed to delivering safe, scalable, and phase-appropriate solutions for high-potent drug development. Our state-of-the-art development facility in Hyderabad, India, is designed to handle highly potent small molecules, ensuring precision, containment, and regulatory compliance at every stage.

Our dedicated high-potency API (HPAPI) development lab operates with Occupational Exposure Limits (OEL) as low as 0.1 µg/m³, making us a trusted partner for high-containment drug development. With a systematic approach to managing HPAPIs, we prioritize safety, efficiency, and scalability, ensuring robust process development and seamless technology transfer.

We specialize in handling a variety of potent molecules, including heterocyclic compounds, nucleosides, steroids, and carbohydrates, offering end-to-end solutions from early-stage discovery to commercial-scale manufacturing

Our Approach for HPAPI handling

Dedicated HPAPI Labs

- State-of-the-Art High Potent Chemical Development Lab :

• Equipped with fume hoods (negative pressure) and barrier isolation.

• Balance connected with an isolator for safe handling.

Advanced Solids Handling & Analytical Capabilities :

• Multi-purpose solids handling suites.

• Dedicated high potent analytical labs with pass box connectivity.

Strict Safety & Containment Measures :

• Capable of handling HPAPI/intermediates with OEL as low as 0.1 µg/m³.

• Separate man-material entry and exit to prevent contamination.

• Mist shower facility for controlled and safe exit.

• Biometric access control for restricted entry.

Dedicated High Potent Analytical Lab

• HPLC equipped with UV, DAD, and CAD detectors

• Gas chromatography with ALS and headspace injectors

• pH meter and analytical balance housed in an Xpert filtered balance system.

• Ultrasound sonicator and rotary shaker for sample preparation

• Isolator with HEPA cartridge ensuring safe handling of HPAI compounds

• Pass box and atmos bag for secure sample transfer

• Fume hood for chemical handling and mobile phase preparation