Synthetic support during the lead optimization

At CRAMSN Research Park, our team excels in offering customized lead optimization solutions for generating the compound with desired quality to achieve better potency, selectivity, pharmacokinetics, and toxicology profiles to meet your specific needs. Each compound we synthesize is thoroughly characterized to ensure the structure and physical properties are precisely validated according to your requirements. Our ultimate aim is to convert promising candidates into high-quality drug leads, fully prepared for preclinical and clinical trials.

• Supply of compounds of interest with assay and purity to support the pre-clinical studies.

• Expertized and hands-on experienced team with multiple chemical transformations to provide quicker solutions.

• State-of-the-art R&D labs equipped with flash purification equipment to cater your needs from mg to grams.

• High-quality compounds generated to meet specific research and development needs.

• Continuous collaboration to align solutions with your strategic research goals.

cGMP supply of material for TOX studies (Pre-clinical studies and Clinical Studies)

We understand the importance of generating toxicology study materials (TOX) that meet the regulatory standards necessary for advancing drug candidates. CRAMSN Research Park offers on-demand synthesis and supply of high-purity materials for toxicology studies, ensuring that you have the compounds needed for preclinical safety testing. Our experienced team ensures that materials are synthesized under strict Good Manufacturing Practices (GMP) and GLP conditions, providing the reliability and consistency necessary for successful TOX studies.

• Our skilled scientists ensure the synthesis process is carried out with the highest level of precision, maintaining quality control at every stage

• We specialize in optimizing processes for scale-up, ensuring smooth transitions from lab-scale to commercial production.

• Our team conducts thorough process safety assessments to guarantee safe execution throughout the synthesis and scale-up phases.

• Our labs are equipped with 250 mL to 5L cylindrical reactors for efficient simulation studies.

• The kilo lab facility is equipped with 10L to 100L cylindrical reactors, designed to meet large-scale synthesis needs while maintaining quality and efficiency.

Chemical Research & Development (CR&D)

Our Chemical Research and Development (CRD) services focus on providing innovative solutions for every phase of drug discovery and development. From initial compound synthesis to scale-up to production, we provide comprehensive support to meet the challenges of chemical process development. Our in-depth knowledge of medicinal chemistry and process optimization allows us to develop scalable, cost-effective solutions that align with your development timeline. Whether you need analytical chemistry support or process chemistry expertise, CRAMSN Research Park is your trusted partner in advancing your projects.

- Route Scouting & Retrosynthetic Approach

Route scouting is a critical component of process development, and at CRAMSN Research Park, we bring expertise and creativity to the table. Our team is skilled in identifying the most efficient synthetic routes for complex molecules, taking into account factors such as yield, cost-effectiveness, and scalability. Whether developing new chemical entities or optimizing existing synthetic pathways, our approach ensures the delivery of high-quality materials that meet your project’s unique requirements. With our advanced synthetic chemistry tools and in-depth knowledge of chemical reactions, we enable faster, more efficient development timelines.

Key Aspects of Our Route Scouting Process:

1. Identifying Efficient Synthetic Routes:

Our team at CRAMSN Research Park excels in route scouting by meticulously identifying the most efficient and reliable synthetic pathways for a given target molecule. We conduct a comprehensive analysis of reaction mechanisms, reaction conditions, and chemical reagents to ensure the chosen routes are practical and effective. We assess factors such as:

• Reaction yields: Ensuring the highest possible yields for each step of the synthesis by thoroughly following the mechanistic approaches.

• Scalability: Identifying methods that can be successfully scaled from lab-scale to pilot-scale through process engineering studies and beyond.

• Reproducibility: Ensuring consistent reactions by identifying and controlling critical process parameters during optimization.

• Environmental impact: implementing the green chemistry principles during optimization to minimise the waste and maximize the use

2. Advanced Tools and Resources:

To support our route scouting process, CRAMSN Research Park utilizes state-of-the-art tools that provide access to an extensive database of chemical reactions, mechanisms, and compound libraries. We use tools like SciFinder and Reaxys to analyze and discover relevant synthetic routes, leveraging their comprehensive databases to identify the most appropriate methodologies.

3. Synthesis Pathway Evaluation:

In route scouting, it is essential to evaluate multiple synthetic pathways to identify the best one for scale-up and commercialization. At CRAMSN Research Park, we perform retrosynthetic analysis to break down complex molecules into simpler intermediates and building blocks, allowing us to identify feasible and efficient synthetic pathways. During the selection of reactions, materials, and reagents, we assess alternative synthetic routes to find the most suitable option for your specific project and mitigate the risks of nitrosamine (NDSRIs) and genotoxic (GTIs) impurity formation.

4. Collaboration and Customization:

We understand that each project has its own set of requirements and challenges. Therefore, our route scouting process is highly collaborative and tailored to meet the specific needs of each client. Whether you are developing new chemical entities (NCEs) or optimizing existing synthetic pathways, we work closely with you to ensure that the routes we select are aligned with your research objectives and business goals.

- Metal-mediated Cross Coupling Reactions

Expertised in handling Pd-, Cu-, Zn-, and Ni-mediated C-C, C-N, and C-O bond-forming reactions, including a broad range of transition metal-catalyzed cross-coupling reactions under a glovebox.

• Specialized in screening ligands and metals for C-H activation reactions.

• Expertise in transition metal-mediated carbonylation reactions.

• Proficient in ring-closing metathesis, click chemistry, and related transformations.

• Our dedicated lab is equipped with a comprehensive library of ligands and catalysts, along with a glovebox to maintain oxygen levels below 1 ppm.

The Labmaster Glove box work station

- Handling of High Pressure Reactions

- Expertised in Synthesizing Niche Chemistries

- Air Sensitive reactions

• Expertised in handling air-sensitive reagents like organolithiums, grignard reagents, organozincs etc.

• Dedicated Laboratory space and manufacturing capacity to handle Cyanation reaction using inorganic cyanides with cyano detectors.

• Able to handle reducing agents like Pd-C, LAH, borane, super-hydrides,etc

• Synthesis of azides and phosphoramidites

- Pharmaceutical Crystallization services